Dr James Shaw



Dr James Shaw is currently the Director of Education and training in the cardiology department. He is an interventional cardiologist with a specific interest in peripheral vascular disease and is involved in inpatient and outpatient care and partakes in the transthoracic and transoesophageal echocardiogram reporting roster. He is a visiting cardiologist to Sandringham hospital and to the Bairnsdale Regional health service.

Following completion of his cardiology training in 1997, he undertook a PhD under the supervision of Professor Dart at the Baker IDI and his thesis titled “Mechanisms of Plaque Stability in Coronary Artery Disease” was successfully completed in 2001. Following this he spent 2.5 years at Massachusetts General Hospital and the Brigham and Womens Hospital in Boston completing further clinical and research training in coronary and non coronary interventional work. In 2004 he returned to Melbourne where he helped establish the Alfred Minimally Invasive Vascular Centre which focuses on endovascular intervention for non coronary atherosclerotic disease. The research interests of Dr Shaw’s group are aligned to the clinical interests and involve active collaboration between various laboratories in the Baker IDI and the clinical department of the Alfred Hospital.

His major areas of research include the impact of changes in lipid profiles on plaque composition the role of platelets in atherosclerosis with a specific interest in HDL and the interaction of non cardiac medications in attenuating the anti platelet effects of clopidogrel and aspirin. More recently the group has begun to examine the role of vitamin D in the presence of coronary and non coronary vascular disease.

Selected Papers

1. Murphy AJ, Bijl N, Yvan-Charvet L, Welch CB, Bhagwat N, Reheman A, Wang Y, Shaw JA, Levine RL, Ni H, Tall AR, Wang N. Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nat Med. 2013 May;19(5):586-94.

2. Fernando H, Bassler N, Habersberger J, Sheffield L, Sharma R, Dart AM, Peter K, Shaw JA. Randomised Double Blind Placebo Controlled Crossover Study To Determine The Effects of Esomeprazole on the Inhibition of Platelet Function by Clopidogrel. Journal of Thrombosis and Haemostasis 2011 Aug;9(8):1582-9.

3. Murphy AJ, Woollard KJ, Suhartoyo A, Stirzaker RA, Shaw J, Sviridov D, Chin-Dusting JP. Neutrophil activation is attenuated by high-density lipoprotein and apolipoprotein a-I in in vitro and in vivo models of inflammation. Arterioscler Thromb Vasc Biol 2011 Jun;31(6):1333-41.

4. White AJ, Duffy SJ, Walton AS, Mukherjee S, Shaw JA, Jennings GL, Dart AM, Kingwell BA. Compliance mismatch between stenotic and distal reference segment is associated with coronary artery disease instability.Atherosclerosis 2009 Sep;206(1):179-85

5. Shaw JA, Bobik A, Murphy A, Kanellakis P, Blombery P, Mukhamedova N, Woollard K, Lyon S, Sviridov D, Dart AM. Infusion of Reconstituted High Density Lipoprotein Leads to Acute Changes in Human Atherosclerotic Plaque. Circulation Research. 2008 Nov 7;103(10):1084-91



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